The intense selection for equine performance traits over many generations has resulted in horses with enhanced muscle mass and improved physical performance; however, reported muscle disorders have also become common.
The surprisingly large number of known heritable muscle diseases in horses currently include polysaccharide storage myopathy type 1 (PSSM1), hyperkalemic periodic paralysis (HYPP), malignant hyperthermia (MH), and immune-mediated myositis (IMM), among many others.
Disease-causing gene mutations (mutant alleles) have been identified for PSSM1, HYPP, MH, and IMM in all horse breeds. These breakthroughs mean that researchers can genetically test for these alleles, decipher whether a particular one is causing disease in an individual horse, and determine how often a mutant allele occurs in different breeds.
The Equine Genetics and Genomics Laboratory at the UMN is conducting a study to determine the genetic mechanisms associated with equine muscle disorders and how diet and exercise affect them. The primary goal of this study is to build a database of 3,000+ horses that will help veterinarians, researchers, and horse owners develop comprehensive treatment strategies for muscle diseases in individual horses.
How You Can Help
We are requesting the help of horse owners to assist in building our database by doing the following:
- Provide information in the Muscle Disease in Horses survey for a horse on your property with suspected or diagnosed muscle disease;
- Provide the same information in the same survey for another horse of similar age and breed on your property without suspected or diagnosed muscle disease;
- Upload photos, videos, and medical files (e.g., blood tests, muscle biopsy results, or genetic testing if available) for each horse to our secure file-receiving folder on Dropbox; and
- Mail in hay, grain, supplement, and hair roots samples to our laboratory.
All horse breeds are welcome to participate. For more detailed instructions on how to participate, information about the study, and questions, please visit our website. You can also follow us on Facebook and email us at firstname.lastname@example.org. This research is funded in part by a grant from Morris Animal Foundation, as well as support from private donors.